Glutamic Acid Dehydrogenase and Glutamic-oxalacetic
نویسندگان
چکیده
As part of a larger project dealing with an in vestigation of amino acid and protein metabolism in leukemia, a study was undertaken to determine those enzymes concerned with amino acid anabo lism and catabolism as they occur in selected tis sues. Several review papers (@,4, 11, 1@)have ade quately summarized our present knowledge of the metabolism of white blood cells (WBC) in leuke mia. However, few efforts have been made to study the enzymes related to amino acid metabo lism in WBC. As an initial investigation we have isolated WBC from leukemic patients and from normal individuals and have examined their con tent of glutamic acid dehydrogenase (GAD) and glutamic-oxalacetic transaminase (GOAT), two of the enzymes concerned with glutamic acid metab olism.
منابع مشابه
Micro determination of glutamic-oxalacetic transaminase in blood serum.
ARGE INCREASES in glutamic-oxalacetic transaminase (GOT) activity in blood serum have been reported for patients suffering from heart or liver tissue damage. The determination of this enzyme as described by Karmen (1) and modified by Steinberg, Baldwin, and Ostrow (2) couples the transaminase reaction with the malic dehydrogenase reaction wherein the disappearance of added reduced diphosphopyri...
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